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Though and although are conjunctions. They go before a clause. Despite and in spite of are prepositions. They go before a noun or noun equivalent. However is a transitional adverb. It goes at the beginning of a sentence.
1. ............................ the watch was expensive, he bought it.
Although
Despite
However
2. We went out ................................... the rain.
in spite of
despite
Either could be used here
3. We went out ............................... it was raining.
although
however
despite
4. ............................ my husband didn't like the movie, I enjoyed it a lot.
Although
Though
Either could be used here
5. He passed the test. ............................, he didn't get the job.
Despite
Although
However
6. .............................. he passed the test, he didn't get the job.
In spite of
Although
However
7. They managed to do it ........................... I was not there.
although
despite
however
8. Tired ............................. he was, he went on working.
though
however
despite
9. .......................... hard she tried, she couldn't do it.
Despite
However
In spite of
10. ................................ of the headache, I enjoyed the movie.
Despite
In spite
However
11. .......................... I don't agree with him, I think he is honest.
Although
However
Despite
12. We understood him ................................ his strong accent.
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